To investigate the effect of Compound Qingdai Capsule in the treatment of psoriasis vulgaris and its effect on quality of life, serum inflammatory factors and hemorheology. Methods: Ninety patients with psoriasis vulgaris were randomly divided into treatment group and control group with 45 cases in each group. The control group was treated with Diyin Tablet, while the treatment group was additionally treated with Compound Qingdai Capsule with 4 weeks as a course and the two groups were treated for 2 courses. The clinical efficacy of the two groups was evaluated and the PASI index was used to evaluate the lesion area and severity of the two groups. Quality of life of the two groups was evaluated by the skin disease quality of life scale （DLQI） and the levels of inflammatory factors and hemorheology were measured and compared between the two groups before and after treatment. Results: The total effective rate was 97.78% （44/45） in the treatment group, which was significantly higher than that in the control group （82.22%, 37/45） （P<0.05）. The PASI and DLQI scores of the two groups were significantly lower than those before the treatment （P<0.01） and the treatment group was significantly lower compared with the control group （P<0.05 or P<0.01）. The IL-2, IL-8 and IFN-γ in 2 group were significantly lower than those before the treatment, IL-4 was significantly higher （P<0.05 or P<0.01）, and the difference between the two groups was significant （P<0.05 or P<0.01）. The plasma viscosity, hematocrit and hematocrit were significantly lower after the treatment （P<0.05 or P<0.01） and significantly lower than those of the control group （P<0.05 or P<0.01）. Conclusion: Compound Qingdai Capsule is effective in the treatment of psoriasis vulgaris, which may significantly reduce the level of inflammatory factors and improve hemorheology level, reduce skin lesions and promote early recovery.