To explore the clinical efficacy and the changes of renal function indexes of Shenshuaining capsules in the treatment of patients with early and medium stage chronic renal failure （CRF）. Methods:Eighty-two cases of patients with early and medium stage CRF who were in our hospital from Mar. 2012 to Dec. 2014 were elected and randomly divided into a control group and an observation group, 41 cases for each. The control group was treated with oxygen bag aldehyde starch on the basis of conventional therapy, while observation group treated with Shenshuaining capsules on the basis of control group. Two months are one course of treatment, and 2 groups were treated for 2 courses continuously. The clinical efficacy and the main clinical symptoms integral in 2 groups were counted, and the levels of Hb, Alb, 24 h UPQ and UA were detected, the changes of renal function indexes in 2 groups before and after treatment compared. Results:The clinical efficacy of the observation group was 85.37%, which was higher than that of control group （46.34%） significantly （P<0.01）. Compared with those before treatment, the scores of lack of appetite and numb to react, numbness of limb of control group decreased significantly after treatment, while the gloomy complexion, lack of appetite and numb to react, languid, soreness and weakness of waist and knees and numbness of limb of observation group decreased significantly after treatment, which were lower than those of the control group （P<0.05 or P<0.01）. Compared with those before treatment, the levels of Hb and Alb of control group decreased significantly, while those of the observation group had no significant change and were higher than those of control group （P<0.05 or P<0.01）. The levels of 24 h UPQ and the levels of Cys-C, BUN and Scr decreased significantly, and which were lower than those of the control group （P<0.01）. The Ccr level of observation group increased significantly, which was higher than that of control group （P<0.05 or P<0.01）. The UA levels of 2 groups had no significant change （P>0.05）. Conclusion:Shenshuaining capsules can improve the main clinical symptoms obviously, impede the CRF progress. Besides it can adjust renal blood circulation and promote the recovery of renal function, and the clinical efficacy is superior to conventional therapy.