To observe the clinical efficacy of Xiaoer Huadu Powder （Infantile Toxin-Expelling Powder） on children constipation. Methods: A total of 98 children with constipation were selected and randomly divided into treatment group （n=49） and control group （n=49） from October 1, 2015 to September 1, 2016. Both groups were treated with comprehensive basic therapy, such as changing the diet, altering the milk powder brand, moderately increasing water drinking and dietary fiber intake, establishing regular bowel movements, raising the amount of activities and strengthening psychological relief. The treatment group additionally treated with Xiaoer Huadu Powder. The treatment course for both groups were 10 days. Results: The total effective rate was 98.0% in the treatment group and 71.4% the control group （P<0.05）. The relapse rate in the treatment group （12.5%） was significantly lower than that in the control group （42.8%） （P<0.05）. There were no significant adverse reactions during the course. Conclusion: Xiaoer Huadu Powder can effectively improve children’s constipation and related symptoms so as to improve clinical efficiency with quick effects and a low relapse rate, worthy of promoting.