To study the effect of Yinzhihuang Keli?on pathological jaundice of newborn. Methods: A total of 78 cases of newborns with pathological jaundice delivered treated in our hospital during May 2013 to February 2016 were chosen asdivided into control group（n=40） and observation group（n=38） by means of random Numbers . The control group was given conventional treatment; the observation group was treated with Yinzhihuang Keli.After 7 days of continuous treatment, comparison between the two groups was made in terms of clinical curative effect,serum bilirubin concentration, the fading time of jundice, alanine aminotransferase （ALT）, total bile acid （TBA）, total bilirubin （TBIL） and adverse reactions. Results: The total effective rate in observation group was higher than that in control group（P<0.05）; the observation group showed signicantly better effect than the control group as regard to improving serum bilirubin concentration （P<0.05）; fading time of jaundice in observation group was shorter that in control group （P<0.05）;the observation group showed lower level of ALT, TBA, TBIL than the control group （P<0.05）. There was no statistical significance regarding the the difference of adverse reaction incidence between the two group during the treatment period （P>0.05）. Conclusion: Yinzhihuang granules shows desirable effect and safety in improvement of pathological jaundice of the newborns and optimization of relavant indices of serum and jaundice.