To observe the clinical efficacy of Yunnan Hongyao capsule in the treatment of ulcerative colitis.Methods:Using randomized study method，60 cases of ulcerative colitis were randomly divided into treatment group and control group，were given Yunnan Hongyao capsule combined with the beauty of salad and glipizide sustained-release granule oral sustained-release granules of salad for 4 weeks.Results:Yunnan Hongyao capsule can obviously improve the patients with ulcerative colitis with abdominal pain，diarrhea，bloody purulent stool，tenesmus and other clinical symptoms，reduce patient stool red blood cells and white blood cells，reduce intestinal mucosal injury，the total efficiency of 90%，there was significant difference compared with the single oral beauty of salad sustained-release granule.Conclusion:The effect of Yunnan Hongyao capsule in the treatment of ulcerative colitis，with no serious adverse reactions，it is worthy of clinical promotion.