To investigate the effect of yiqiyangxin decoction combined with conventional western medicine therapy on cardiac function and myocardial enzymes in the treatment of patients with chronic heart failure （CHF）. Methods:All 122 cases of CHF patients in Lingshan County hospital of TCM from February 2015 to October 2016 were randomly divided into a control group and an observation group, 61 cases in each group, and the control group received conventional western medicine treatment, the observation group extra yiqiyangxin decoction, both treated for 4 weeks. The clinical effects were compared between 2 groups. The cardiac function, myocardial enzymes, neuroendocrine hormones and vascular endothelial function were measured and compared between 2 groups. The quality of life （QOL） of the patients before and after treatment in 2 groups was evaluated by the Minnesota Life Scale （MHL）. Results:The total effective rate of observation group was 90.16%, which was significantly higher than 78.69% of control group （P<0.05）. After treatment, the LVESD and ESV in observation group were significantly lower than those of the control group （P<0.05 or P<0.01）. SV, CI, LVEF, FS in the observation group were significantly higher （P<0.05 or P<0.01）, and LVEF, FS was significantly higher than those of control group （P<0.05 or P<0.01）. After treatment, the CK, CK-MB, LDH and α-HBDH in 2 groups were significantly decreased, and the observation group was significantly lower than the control group （P<0.05 or P<0.01）. Compared with before treatment, the levels of PRA, AngⅡ, ET, ALD in observation group significantly reduced, and the difference between 2 groups was significant （P<0.01）. After treatment, the MHL scores of 2 groups were lower than those before treatment （P<0.01）, and observation group was significantly lower than that of control group （P<0.01）. Conclusion:The use of yiqiyangxin decoction in the treatment of CHF on the basis of routine treatment can delay the degree of myocardial injury, improve cardiac function, inhibit excessive activation of the neuroendocrine system, and protect vascular endothelial function, so as to improve the clinical efficacy, worthy of clinical application.