To study the clinical efficacy of Compound Radix Arnebiae Oil in treating infantile eczema. Methods: A total of 60 pediatric patients with eczema were treated with Compound Radix Arnebiae Oil for external application for 1 to 2 courses, one of which included 7 days. The therapeutic effects were observed before and after the treatment, and the relapse rate was observed through 3-month follow-ups. Results: A total of 55 cases completed the treatment, in which 8 cases were cured, 29 cases were treated markedly effective, 13 cases effective and 5 cases ineffective. The total effective rate was 90.9%. During 3-month follow-ups, 7 cases were failed to follow and 5 cases relapsed. The relapse rate was 10.20%. Conclusion: Compound Radix Arnebiae Oil is effective in treating infantile eczema, and the recurrence rate is low. As a topical medication, it has less side effects, easier for children’s application and worthy of promotion.