To explore the effect of TCM loction for the treatment of atherosclerotic disease in lower extremity of stagnation of collaterals due to phlegm and blood stasis pattern. Methods: A total number of 127 c atherosclerotic disease in lower extremity of stagnation of collaterals due to phlegm and blood stasis pattern in outpatient and inpatient were collected and randomly divided into three groups: treatment group （n=42）, conventional group （n=43） and control group （n=42）. Patients in the treatment group were given with western medicine and TCM wash lotion, patients in the conventional group with western medicine and warm water washing and patients in the control group simply with western medicine. Two weeks were set as a course of treatment for 6 courses with 2-day interval between each course. The changes of arterial diameter, intima-media thickness and blood flow velocity were observed before and after treatment. Results: The diameter of the common, superior femoral artery and deep femoral artery of the lower limbs of the three groups were significantly increased, the thickness of the medial-intima was significantly decreased and the blood flow velocity was significantly increased after the treatment, which the difference was statistically significant （P<0.05）. The treatment group was significantly superior to the conventional group and the conventional group was significantly better than the control group, showing that the difference was statistically significant （P<0.05）. There were no liver and kidney dysfunction and other adverse reaction in the three groups before and after treatment. Conclusion: The TCM lotion and foot bath with warm water have the effect of improving atherosclerotic disease in lower extremity, with certain clinical application value.