To observe the clinical effect of Huatengzi Granules plus desloratadine citrate disodium on allergic rhinitis.Methods:A total of 80 patients with allergic rhinitis in Jiangsu Provincial Hospital of Traditional Chinese Medicine from September, 2015 to September, 2016 were randomly divided into treatment group （n=40） and control group （n=40） by the random number table. The control group received desloratadine citrate disodium, and the treatment group was treated with Huatengzi Granules plus desloratadine citrate disodium. Both groups were treated for 4 weeks. After treatment, the VAS scores, RQLQ scores, symptom and syndrome scores and total effective rates were measured to evaluate the clinical efficacy, and the total number of cases of adverse reactions was statistically analyzed.Results:A total of 39 patients in each group finished the trial, There were statistical differences between the two groups’ VAS scores, RQLQ scores, and symptom and syndrome scores before and after treatment （P<0.05）. After treatment, there were no statistical differences in nasal itching, watery nasal discharge and the total effective rates （P> 0.05）. But there were statistical differences in the aspects of VAS scores, RQLQ scores, sneezing, nasal congestion, and symptom and syndrome scores between the two groups （ P<0.05）. There was no case of adverse reaction except for one patient in the treatment group with mild diarrhea.Conclusion:Huatengzi Granules plus desloratadine citrate disodium has good clinical efficacy and safety for the treatment of allergic rhinitis.