Revascularization combined with anti-platelet and lipid-lowering drugs prominently improved the prognosis of patients with acute myocardial infarction （AMI）. However, early and long-term thrombosis, no/slow-reflow phenomenon and in-stent restenosis remain the major problems which impact on the prognosis of AMI patients. Therefore, how to take the complementary advantage of traditional Chinese medicine （TCM） and western medicine （WM） to further improve the prognosis is still a big challenge for TCM clinical practice. On a background of standard treatment, professor Shi performs well in differentiating TCM syndrome of patients with AMI and emphasizing pathogenic characteristics of toxin factors, and flexibly adopts the treatment of benefiting qi, activating blood, detoxifying, promoting myocardial tissue regeneration and purgation fu-organs, by which, certain good clinical has been achieved in the patients with AMI.