To study the Jiangtangxiaoke granule in the treatment of high fat diet induced type 2 diabetes and to investigate its effect on renal N-terminal kinase signal pathway. Methods: All 72 Wistar rats were reared in SPF conditions, and were randomly divided into an intervention group, a control group and a normal control group, 24 rats in each. By streptozotocin （STZ） intraperitoneal injection of 30 mg/kg synergy, high fat diet induced type 2 diabetes animal models were built. After the model intervention, the normal control group received standard diet; the control group was treated with high glucose and high fat diet; the intervention group treated with high glucose, high fat diet, and Jiangtangxiaoke granules were calculated according to the body weight of 9 g/kg rats by gavage once daily. Treatment lasted 8 weeks. Using enzyme-linked immunosorbent assay （ELISA method） to detect rats blood glucose （Glu）, triglyceride （TG）, total cholesterol （TC）, serum creatinine （Scr）; routine HE staining, observing the changes of renal structure in each group; real time fluorescent polymerase chain reaction （q-PCR） detection （amino terminal kinase） and JNK （glucagon like peptide-1 GLP-1） and Western blotting （Western Blot） to detect the activation of JNK signaling pathway, JNK （phosphorylated N-terminal kinase） p-JNK and GLP-1.Results: 1） The Glu, TC, TG and Scr in the intervention group were significantly lower than those in the control group （P<0.05）. 2） Compared with the control group, the changes of glomerular structure were significantly improved in the intervention group （P<0.05）. 3） Compared with the normal control group, the expression of p-JNK protein in control group increased significantly （P<0.05）, GLP-1 gene and protein significantly decreased （P<0.05）; after treatment, the intervention group of p-JNK protein was lower than that of the control group （P<0.05）, and GLP-1 （P<0.05） gene and protein increased. Conclusion: Jiangtangxiaoke granules can regulate sugar, lipid metabolism, protect the kidney function, its mechanism may be related to the inhibition of the JNK signaling pathway and regulation of GLP-1.