To study the effect of Qianlietong Tablets in regulating immune function on mice. Methods: 1） Splenic Lymphocyte transformation test: A total of 60 SPF grade BALB/c mice were randomly divided into negative control group, positive control group, and Qianlietong Tablets low-, medium-, and high-dose groups. After Intragastric administration of different medications for different groups for 30 days continuously, spleens of each group were obtained in aseptic condition. Then spleen lymphocytes were extracted for transformation test. 2） NK cell activity effect test: A total of 60 SPF grade BALB/c mice were randomly divided into negative control group, model group, positive control group and Qianlietong Tablets low-, medium-, and high-dose groups. Except the negative group, mice model with low immune function was built in other groups by intraperitoneal injection of cyclophosphamide, and the mice models were given medicines as well. After 30 days of medication, spleens were obtained in aseptic condition. Spleen lymphocytes were extracted for testing influence on NK cell activity. Results: 1） Compared with the negative control group, the spleen lymphocytes transformation ability of the Qianlietong Tablets high-dose group increased obviously with significant difference（P<0.05）. 2） Compared with the model group, the NK cell activity of the positive control group and the Qianlietong Tablets high-dose group increased obviously with statistical difference （P<0.05）. Conclusion: Under the experimental condition, Qianlietong Tablets can improve lymphocytes transformation ability and NK cell activity, which proves that Qianlietong Tablets has the effect of promoting immune function.