To test the antibacterial effects of four extracts of Lianqiao Siwei decoction on common clinical bacteria. Methods:Using agar plate dilution method and microwell plate TTC method and taking the extracts of Lianqiao Siwei decoction in different solvent （aether petrolei, chloroform, acetic ether, absolute ethanol, 75% ethanol and water） as experimental drugs, then selecting 11 common pathogenic strains which are isolated and identified in clinic. To detect the minimum inhibitory concentration （MIC） and the minimum bactericidal concentration （MBC） of them. Results:Six extracts used in the test showed universal inhibitory effects and certain bactericidal effects against 11 tested strains. They are Staphylococcus aureus, Staphylococcus epidermidis, enterococcus, bacillus subtilis, Bacillus anthracis, Escherichia coli, Klebsiella pneumonia, baumanii, Pseudomonas aeruginosa, Bacillus levans, and Candida albicans. Conclusion:Different extracts of Lianqiao Siwei decoction have antibacterial effects. As a traditional formula, it worth to be further studied in pharmacodynamics and pharmacology.