To investigate the clinical efficacy of Wang Xierong’s acupotomy and chiropractic manipulation in treating cervicogenic headache. Methods:A total of 300 patients with cervicogenic headache admitted to Navy General Hospital of PLA from month, 20 to month, 20 were randomly divided into acupotomy-chirapractic group （n=150） and nerve block group （n=150）, each of which was treated respectively with acupotomy combined with cervical spinal manipulation and the injection of nerve-numbing substance （one time a week, three times a course for both treatments）. The VAS score and clinical efficacy of 3 months and 6 months after treatment were observed and analyzed statistically. Results:The short-term and long-term total effective rates of acupotomy-chiropractic group treating cervicogenic headache were 97.3% and 92.0% respectively, with those of nerve block group being 91.3% and 68.7%. Through comparison, the differences of VAS score before and after treatment as well as between groups were statistically significant （P<0.05）. Conclusion:Acupotomy combined with Wang’s cervical spine manipulation in the treatment of cervicogenic headache has satisfactory, safe and stable curative effect that is worth application.