To systematically review the efficacy of the integrated Chinese and western medicine treatment for primary nephrotic syndrome in children. Methods:Papers on databases including CNKI （2006-2016）, VIP （2006-2016） WanFang （2006-2016）, Sinomed （2006-2016） and PubMed （2006-2016） were searched to identify the randomized controlled trials（RCTs） on integrated Chinese and western medicine treatment for primary nephrotic syndrome in children. According to the inclusion and exclusion criteria, the data of those papers were extracted, their quality were assessed. Then meta-analysis was performed using RevMan5.3 software. Results:A total of 19 papers involving 1466 patients were included （754 in the treatment group and 712 in the control group）. Baseline data of the studies were comparable. The results of the meta-analysis indicated that integrated Chinese and western medicine therapy were superior to conventional glucocorticoid treatment in improving efficacy（RR=1.27,95%CI［1.20,1.35］）, decreasing 24 h’s UTP（SMD=-0.71, 95%CI［-0.84，-0.59］）, elevating（ALB） （SMD=0.90, 95%CI［0.70, 1.10］）, increasing TC:MD=-1.49, 95%CI［-1.96，-1.01］;TG:SMD=-0.71,95%CI［-1.01，-0.41］）, reducing adverse reactions（OR=0.16,95%［0.10,0.27］, and reducing relapse rate （RR=0.49,95%CI［0.37,0.64］）. Conclusion:Meta-analysis results suggested that the efficacy of the integrated Chinese and western medicine treatment for primary nephrotic syndrome in children is better. Because of the limited quantity and quality of the included studies, the above conclusion still needs to be verified by conducting more high-quality studies.