Abstract:To analyze clinical and pathological charateristics of triple negative breast cancer (TNBC) patients with different ages and different baseline metastasis status. Methods:A retrospective cohort study was conducted, in which TNBC patients were grouped according to their ages (younger than 35 years old, 35~60, older than 60) and baseline metastasis status (with or without baseline metastasis). Clinical and pathological charateristics were compared as well as the clinical symptoms of Chinese Medicine. Results:Among the 108 TNBC patients enrolled, their average age was around 47; most patients received modified radical mastectomy; major pathological type was invasive ductal carcinoma, 36.1% patients showed positive ALN, 8 patients (7.4%) had metastasis after surgery. Patients younger than 35 preferred conserving surgery. Compared with patients without baseline metastasis, patients with baseline metastasis received more surgeries, with higher pathological stages, and later receipt of TCM treatment. There was no significant difference of TCM symptoms among the patients with different ages. Patients with baseline metastasis showed higher rate of anorexia and gastrointestinal symptoms, such as nausea and vomit. Conclusion:There were significant differences of clinical characteristics among TNBC patients with different ages and baseline metastasis status, but no differences on clinical symptoms of TCM. The impact of these clinical differences on long term outcomes needs further follow-up.