To discuss the clinical effect of “guiding fire to origin method” treating children with Henoch-Schonlein purpura nephritis hematuresis(Syndrome of liver and kidney yin deficiency).Methods:The 80 cases of children,with HSPN in accordance with the inclusive criteria，selected from Affiliated Hospital of Chengdu University of Traditional Chinese Medicine from October 2015 to December were divided into the experiment group and the control group by the proportion of 1:1.The experiment group were treated with New Zhibo Dihuang decoction,and the control group were treated with original Zhibo Dihuang decoction,8 weeks for the treating,then TCM symptom score and hematuresis befor and after the treatment in the two groups were observed.Results:There is also a statistically significant difference between the experient group and the control group on curative effect of TCM syndrome,hematuresis and urine erythrocyte(P<0.05).Conclusion:New Zhibo Dihuang decoction has excellent efficacy in treating children with hematuresis caused by Henoch-Schonlein purpura nephritis(Syndrome of liver and kidney yin deficiency)and no significant adverse reactions caused by the treatment，which confirms that the method of “guiding fire to origin” have certain effect in treating children with HSPN，and it is worthy generalizing clinically.