To observe curative effect of Maxing Shixuan Decoction on children’s cough caused by damp-heat syndrome.Methods:A total of 72 children diagnosed as cough caused by damp-heat syndrome were collected from Sept 2016 to Feb 2017 in Affiliated Hospital of Chengdu University of Traditional Chinese Medicine,and they were randomly divided into test group of 36 and control group of 36.The test group were given the treatment of Maxing Shixuan Decoction，at the same time，the control group were given the Haoqin Huashi oral liquid.After a treatment period of 7 days，compared the efficacy of both groups with before and evaluated the clinical effect of Maxing Shixuan Decoction.Results:Compared the general efficacy between the two groups，there was significant differences(P<0.05)，which showed that the general efficacy of the test group was superior to the control group.As for improving the single symptoms，the two groups had no significant difference at diet and urine，which were belong to minor symptoms(P>0.05)，but the test group was obviously superior to the control group in terms of cough and phlegm belong to main symptoms as well as heating and anorexia belong to minor symptoms，the tested term significantly had better efficacy than control group(P<0.01).Also,test group had better efficacy than control group in terms of sneezing，runny nose,stool stem node，tongue and pulse，which belong to minor symptoms(P<0.05).Conclusion:Maxing Shixuan decoction has good curative effect on curing cough caused by damp-heat syndrome and it is worthy spreading and further studying.