To compare the efficacy of different medicinal regimens in the treatment of knee osteoarthritis (OAK) to provide reference data for clinical medication.Methods:A total of 103 patients (132 knees) with osteoarthritis of the knee (OAK) who were admitted in the hospital from January 2015 to December 2016 were included in the study. The radio of male / female is 1.24:1 (57/46) with the average age of (43.60±10.35) years and average course of disease of (20.1±3.4) months. All the patients were divided into two groups according to the random number table and named as the observation I group and the observation II group. All the patients were treated with limb control, supplemented by the extraction of effusion or washing in the inferior articular cavity under ultrasound therapy and each group had different medicinal regimens. Patients in the observation I group had application of antipyretics such as Ibuprofen Sustained-Release Capsules (oral-taking twice a day, 1 tablet a time), Glucosamine Hydrochloride Capsules (1 capsule one time, 3 times /day). Patients in the observation II group were additionally treated with acupuncture and massage therapy (once the other day, 3 times a week). The course of treatment lasted for 6 weeks. The efficacy and safety of the treatment were investigated.Results:there were statistically significant differences in the knee joint score after 2-week, 4-week, and 6-week treatment and improvement in clinical symptoms and signs after 6-week treatment between the two groups (P<0.05). The total incidence rates of adverse events in two groups (9.62% and 7.69% in observation I group and observation II group respectively) showed no significant difference (χ2=0.24,P=0.63, >0.05).Conclusion:may accept with Anti-inflammatory and analgesic western medicine combined with acupuncture and massage therapy for osteoarthritis of the knee obtains good results in pain relief and significantly improve the function of the knee, improving the quality of life of patients.