To study the effect and safety of Dingchuan Zhike decoction combined with budesonide suspension in treating infantile asthmatic bronchitis.Methods:A total of 98 infants and children with asthmatic bronchitis who received treatment from September 2014 and September 2016 were included and randomly divided into observation group and control group. The treatment group was treated with Dingchuan Zhike Decoction and budesonide suspension, while the control group was only treated with budesonide suspension. The efficacy, symptom relief time and adverse reactions were compared between the two groups.Results:The total effective rate of the observation group and the control group was 95.92% and 83.67% respectively after 7-day treatment and the one of the observation group was significantly higher, which showed that there was significant difference (P<0.05). The time asthma, cough and lung wheezing disappearance in the observation group was shorter than those in the control group (P<0.05). The Rrs SO in the observation group was significantly lower than that of the control group after the treatment and Crs SO was significantly higher than the control group, with significant difference (P<0.05). The recurrence rate in the observation group was significantly lower than that in the control group during the 3-month follow-up (P<0.05).Conclusion:Dingchuan Zhike Decoction combined with budesonide suspension may improve relieving clinical symptoms, improve the therapeutic effect and reduce the recurrence rate, with high safety.