To observe the clinical effect of modified Danggui Shaoyao San in the treatment of liver cirrhosis based on “Intestine-liver axis”.Methods:Selected fifty cases of patients with liver cirrhosis admitted in our hospital from March 2014 to March 2016.Then divided patients into observation group and control group, with 30 cases in control group and 20 cases in observation group.Routine western medicine was given the control group, and on the basis of that, the observation group of patients were also treated with Bangui Shaoyao San.Both groups were treated for 1 month.Compare the clinical curative effect, Chid-Pugh, grading, liver function index before and after the treatment of the two groups, as well as the changes of the level and changes of intestinal flora before and after treatment.Results:The total effective rate of the observation group was 86.67% (26/30), higher than that of the control group 60.00% (12/20)(P<0.05).After treatment, Chid-Pugh A class in the observation group is 60.00% (18/30), higher than that of the control group 30.00%(6/20)(P<0.05).After treatment, ALT and TBIL levels in the observation group are (68.9±13.2) U/L, (49.3±5.0) μmmol/L, lower than those of the control group (112.7±13.5) U/L, (61.4±5.4) μmmol/L (P<0.05).After treatment, bifidobacteria level of the observation group is higher than the control group, and e.coli level is lower than the control group (P<0.05).Conclusion:The mechanism of Danggui Shaoyao San may be related to intestinal flora balance improvement, intestinal mucosal barrier restrore and endotoxin relievement.