To observe the clinical efficacy of Yixinshu capsule in the treatment of diabetes II mellitus combined with coronary heart disease angina pectoris.Methods:A total of 88 cases patients with diabetes II mellitus and coronary heart disease angina pectoris were elected and divided randomly into control group (n＝44) and observation group (n＝44).The control group were treated with routine hypoglycemic and antianinal drugs and the observation group were treated with Yixinshu capsule on the basis of the control.Both groups were treated for 8 weeks.Analyze clinical efficacy of the two groups after treatment and detecte and compare the changes of blood glucose, blood fat and platelet activation indexes before and after treatment.Results:After treatment, clinical symptoms and electrocardiogram excellent ratio and effective rate increased significantly, and null cases ratio decreased (P<0.05 or P<0.01).After treatment, the levels of serum FBG, 2 h PBG, HbA1c and TG, TC, LDL-C of two groups decreased significantly, and those of the the observation group decreased more greatly than the control group (P<0.05 or P<0.01).Besides, the levels of HDL-C in the two groups increased, and that of the observation group was higher than that of the control group (P<0.01).After treatment, levels of PAC-1 and MAR of control group decreased (P<0.05) as well as LAP, CD62P, PAC-1 and MAR which were lower than that of the control group (P<0.01).Conclusion:Yixinshu capsule can decrease blood glucose, and blood fat of patients with diabetesII mellitus and coronary heart disease angina pectoris, plus inhibiting platelet activation and enhancing clinical efficacy.