To explore the clinical efficacy of Yiqi Bushen Zhichuan Decoction combined with western medicine in treating infantile asthma and its effects on serum ET-1, NO, CEC levels.Methods:A total of 158 cases children with asthma were divided into control group and observation group, with 79 cases in each group. The control group was treated with conventional western medicine, while the observation group was additionally treated with Yiqi Bushen Zhichuan Decoction. Patients in the two groups were all treated for 3 months. The clinical efficient of the two groups were calculated; the changes of lung function indexes and serum ET-1, NO, CEC levels in two groups before and after treatment were compared; the recurrence of asthma were compared after 1-year followed-up after the treatment.Results:The clinical total effective rate of observation group was 96.20%, which was higher than that 75.95% of control group (P<0.01). The FVC, FEV1, FEV1/FVC, MMEF and PEF increased significantly after the treatment, and the serum ET-1, NO and CEC levels decreased significantly, which both showed significant difference between the two groups (P<0.05 orP<0.01). The following-up showed that times of the respiratory tract infection and the recurrence of asthma decreased compared with those of the control group and the duration time of asthma shortened significantly (P<0.01).Conclusion:Yiqi Bushen Zhichuan Decoction combined with western medicine can reduce the expression levels of serum ET-1, NO and CEC of children with asthma, reduce airway damage, improve the lung function, and decrease the recurrence of asthma. Its clinical efficacy is superior to the conventional western medicine treatment.