To explore the effect of Xuezhikang Capsule combined with atorvastatin in treatment of hyperlipidemia and its influence on blood lipids and inflammatory factors.Methods:A total of 488 patients with hyperlipidemia who had treatment in the hospital were selected and divided into treatment group (n＝244) and control group (n＝244) according to the random number table method. The two groups were both treated with atorvastatin while the treatment group was additionally treated with Xuezhikang Capsule. Patients in the two groups were treated continuously for 3 months. The clinical effects of the two groups were compared. The levels of blood lipids, inflammatory factors and vascular endothelial function indexes were detected and compared between the two groups before and after treatment. Adverse reactions were compared between the two groups. Results:The clinical total efficiency of the treatment group was 95.49%, which was significantly higher than 83.20% of the control group (P<0.05). The levels of serum TC, TG, LDL-C in the two groups after the treatment decreased significantly and HDL-C increased significantly. The improvement of the treatment group was better than that of the control group (P<0.01). The levels of serum IL-6, IL-18 and ET in the two groups after the treatment decreased significantly, NO increased significantly, and the improvement of the treatment group was better than that of the control group (P<0.01). There was no obvious adverse reaction in the treatment group but the adverse reaction rate of the control group was 13.93%, which was significantly higher than that in the treatment group (P<0.05). Conclusion:Xuezhikang Capsule combined with atorvastatin can significantly improve blood lipid levels and vascular endothelial function of patients with hyperlipidemia and reduce inflammatory response and adverse reaction, showing that its clinical effect is remarkable.