To explore the clinical efficacy of Xuanfei Tongqiao Decoction combined with microwave in the treatment of acute secretory otitis media (ASOM) and analyze the effect on the clinical symptoms and inflammatory factors. Methods:A total of 102 ASOM cases in the hospital from Jun. 2016 to Jan. 2017 were selected and divided randomly into control group and treatment group, with 51 cases in each group. Patients in the control group were treated with conventional western medicine, while patients in the treatment group were additionally treated with Xuanfei Tongqiao Decoction combined with microwave. Patients in both the two groups were treated for two weeks continuously. The clinical efficacy and the improvement of clinical symptoms of the two groups were compared. Changes in serum and secretions inflammatory factors levels were detected and compared. Results:The inefficiency of the control group was 29.41% after the treatment, which was higher than that 7.84% of treatment group (P<0.01); while the total effective rate treatment group was 92.16%, which was higher than that 70.59% of control group (P<0.01). The clinical symptoms integral and average air conduction threshold decreased significantly after the treatment and treatment group was lower (P<0.01), while the improvement in listening of the treatment group was higher than that of control group (P<0.01). The secretions IL-6, IL-10 and TNF-α levels decreased significantly after the treatment; treatment group was lower than control group (P<0.01); the serum IL-6, IL-10 and TNF-α levels between two groups and before and after the treatment showed no significant difference (P>0.05). Conclusion:The clinical efficacy of Xuanfei Tongqiao Decoction combined with microwave in the treatment of ASOM is remarkable, which may relieve the clinical symptoms in some degree, improve listening ability, reduce the secretions inflammatory factor, inhibit inflammatory reaction and promote the patient outcome.