To observe the clinical curative effect of Heqi Powder combined with Metformin in treating PCOS with insulin resistance.Methods:Ninety patients who met the criteria were included and randomly divided into group A (Chinese medicine group), group B (western medicine group) and group C (Chinese-western medicine group), with 30 cases in each group. Chinese medicine group took Heqi Powder, western medicine group took metformin, while the Chinese-western medicine group took Heqi Powder plus metformin. Clinical syndromes, glucose metabolic and insulin resistant parameters and sex hormone levels of the two groups before and after the treatment were compared.Results:After 3-month treatment, improvement in clinical syndromes of the Chinese-western medicine group was better than Chinese group and western medicine group (P<0.05). Insulin level and HOMA-IR in the western group and Chinese-western medicine group decreased effectively (P<0.01), ISI increased (P<0.01). The Chinese-western medicine group received better results, showing that the difference between the two groups was significant (P<0.05). LH (P<0.01) and T level (P<0.05,P<0.01) in the Chinese group and the Chinese-western medicine group decreased, but T level only decreased in the western medicine group (P<0.01).Conclusion:Heqi Powder combined with Metformin may improve patients’ clinical syndromes and insulin resistance and regulate insulin and sex hormone levels for patients with PCOS with insulin resistance.