To observe the effect of Yinchen Wuwei decoction on neonatal jaundice infection, and its effect on hs-CRP and MCP-1 gene expression.Methods:A total of 76 cases of neonatal infectious jaundice in our hospital from January 2016 to February 2017 were selected.The patients were randomly divided into treatment group and control group, with 38 cases in each group.Treatment for the control group:blue light treatment combined with cefazolin sodium; Treatment for the treatment group:on the basis of the control group, orally taken Yinchen decoction of five ingredients.After a course of 5 days, the clinical efficacy was assessed at the same time using transcutaneous jaundice meter between children eyebrows for 3 times in the morning and evening.The average value is taken as the children with transcutaneous bilirubin (TCB).Before and after treatment, the serum hsCRP (high sensitivity C reactive protein) was detected by latex immunoassay, and the white blood cell count (WBC) before and after treatment was detected by the automatic biochemical analyzer.The expression of monocyte chemoattractant protein-1 (MCP-1) gene was detected by TaqMan fluorescent probe.Results:1) The curative effect was compared between the two groups before and after treatment.The total effective rate of the treatment group (97.37%) was higher than that of the control group (94.74%), but there was no significant difference (P>0.05) .2) After treatment, the values of transcutaneous bilirubin in the two groups were significantly lower than those before treatment (P<0.05), the treatment group was significantly lower than the control group (P<0.05).3) There was no significant difference in hs-CRP, WBC and MCP-1 between the two groups before treatment (P>0.05).After treatment, hs-CRP and WBC of the two groups were significantly lower (P<0.05).After treatment, hs-CRP, WBC, MCP-1 decreased significantly, and it is more obvious in the observation group (P<0.05).Conclusion:Yinchenwuwei decoction can effectively relieve neonatal jaundice infection, reduce the percutaneous value and the count of WBC, the mechanism may be related to down-regulation of s-CRP and MCP-1.