To observe the effect of Zisheng Shenqi Decoction on expression of IL-1β and Caspase-1 in gouty arthritis rats and to explore the mechanism of Zisheng Shenqi Decoction in the treatment of GA.Methods:Eighty four rats were randomly divided into seven groups:blank control group,model group,herbal control group,western medicine control group,high dosage herbal group,medium dosage herbal group and low dosage herbal group,twelve rats in each group.The uric acid sodium and oxygen polybenzoxazines potassium were used to induce rat gouty arthritis model.ELISA was used to detect the concentration of serum IL-1β in rats and analyze the data.Using immunohistochemical method to detect the contents of synovial Caspase-1 in rats.Results:The differences of IL-1β and Caspase-1 level between model group and blank group had statistical significance(P<0.01).The expression of IL-1β and Caspase-1 in model group was also apparently different from that in western medicine control group,highdosage herbal group,medium dosage herbal group and low dosage herbal group,the differences had statistical significance(P<0.01);The expression of IL-1β and Caspase-1 in medium dosage herbal group was apparently different from that in herbal control group(P<0.01),but had not apparently difference from western medicine control group(P>0.01).Conclusion:Zisheng Shenqi Decoction can inhibit the expression of IL-1β and Caspase-1 in gouty arthritis rats.It has certain curative effect gouty arthritis.