To observe the effects of Guanxinjing(GXJ) capsule on behavioral phenomenon of post-myocardial infarction depression model rats. Methods:Model was induced by chronic mild and unpredictability stress after coronary artery ligation in rats, and behavior index of rats as well as the level of 5-HT before and after treatment was measured respectively. Results:The score of horizontal and vertical motion score, weight, rate of liquid consumption, sucrose preference test score and level of 5-HT in model group were significantly lower than blank control group(P<0.01). Compared with model group, the GXJ capsule group and fluoxetine group can improve the score of open field test, increase the body weight of rats, and improve the sucrose preference test score as well as the level of 5-HT(P<0.05). There was no significant difference between the two groups. Conclusion:GXJ capsule can improve behavioral manifestations and 5-HT level of post-myocardial infarction depression model rats. Further study on GXJ capsule treating psycho-Cardiological disease is worthy to go on.