To study the clinical efficacy of acupuncture combined with Chinese medicinal on peripheral facial paralysis and its effect on immunoglobulin.Methods:A total of 110 cases of peripheral facial paralysis treated in the hospital from Oct. 2014 to Oct. 2016 were selected and divided into acupuncture group (n＝58) and acupuncture-medicine group (n＝52) according to different treatment methods. Acupuncture group was only given by acupuncture therapy, while acupuncture-medicine group was given by acupuncture and Chinese medicinal at the same time. The clinical effect after the treatment, facial nerve function and the levels of immunoglobulin IgA, IgG and IgM before and after the treatment were compared between the two groups.Results:The total effective rate was 96.15% in acupuncture-medicine group, which was significantly higher than 81.03% in acupuncture group, showing that the difference between the two groups had statistically significant (P<0.01). The House-Brackmann (H-B) score from two to four weeks after the treatment of the acupuncture group was significantly higher than that before the treatment, while it was significantly higher from 1 to 4 weeks after the treatment in the acupuncture-medicine group (P<0.05 orP<0.01), and significantly higher than those of the acupuncture group, showing statistically significant difference (P<0.05 orP<0.01). The levels of serum IgA, IgG and IgM in the two groups significantly decreased (P<0.01), and the acupuncture-medicine group was significantly lower than those in the acupuncture group, which showed that there was statistically significant difference (P<0.05 orP<0.01).Conclusion:Acupuncture combined with Chinese Medicinal may rapidly relieve clinical symptoms and signs of patients with peripheral facial paralysis, improve facial nerve function, reduce the level of immunoglobulin and improve the overall therapeutic effect.