To explore the effectiveness of the combination of needle-knife loosening technique combined with manipulation in the treatment of scoliosis and to record follow-up conditions.Methods:Thirty-four patients with scoliosis from January 2012 to September 2016 were selected and divided into two groups. The treatment group was treated with needle-knife loosening technique. The control group was treated with brace for comparison. The efficacy and feasibility of the two groups were compared from VAS score and Cobb angle before and after the treatment.Results:The excellent-good rate of the study group was 94.12%, higher than that of the control group (82.35%); the treatment effect of the former was 70.59%, which was much higher than that of the latter (29.41%,P<0.05); the average score of the treatment group was 2.6±0.5, lower than that of the control group (4.8±1.9) (P<0.05); the correction rate of the treatment group was 50.4%, while that of the control group was 20.7% (P<0.05). The comparison of Cobb angle before and after the treatment in both the two groups showed difference (P<0.05). During the half-year follow-up, the increase of average height in the treatment group was （5.1±0.6）cm, and（4.6±0.7）cm in the control group (P >0.05).Conclusion:The combination of needle-knife loosening technique may relieve the pain of patients, increase the height and improve the prognosis and have a good effect on correction, which is a reliable and effective.