To observe the clinic effect of regulating qi and activating blood formula in treating functional constipation and evaluate its efficacy and safety basing on systematic review.Methods:Researchers searched randomized controlled trials related to regulating qi and activating blood herbal decoction in the treatment of functional constipation in Chinese and English databases during January 2010 to December 2014.Choosing cure rate,effective rate,recurrence rate and adverse reaction as final indicators.To evaluate efficacy and safety by Revman 5.10 software.Results:Eighteen RCTs and 1 711 patients were included in this systematic review.Meta analysis shows there are significant differences in cure rate,effective rate,recurrence rate and adverse reactions between treatment group and control group (P<0.05).Also,adverse reaction rate was significantly lower in the treatment group (P<0.05).Conclusion:Using regulating qi and activating blood herbal formula to treat functional constipation has significant efficacy and safety,with lower recurrence rate.