To optimize the extraction process of Yangyin Anshen granules.Methods:To observe the effect of Yangyin Anshen granules on sleeping of petobar-bital sodium mice in order to optimize the best extraction technololgy of Yangyin Anshen prescription.Pharmacological results shows that with composite score of extraction rate of spinosin which in the Gentleman medicine ziziphi spinosae semen and dry extract rate as comprehensive evaluation indexes, orthogonal test was used to optimize the water extracting technology.Then with composites score of retention rate of spinosin and impurity removing efficiency as comprehensive evaluation indexes, orthogonal test was used to optimize the alcohol precipitation technology.Results:Optimum water extraction technology conditions were as follows:boiled the herbs with eight times the amount of water for thrice, one hour for each time, and three times in total.Optimum alcohol precipitation technology conditions were as follows:condensed the relation density of the liquor as in 1.25(60 ℃), adding alcohol to 80% of alcohol concentration and depositing it in the refrigerator at 4 ℃ for 36 h.Conclusion:Optimized extraction technology is stable and feasible, which can provide basis for molding technology of Yangyin Anshen granules.