To research the characteristics of the traditional Chinese medicine (TCM) pathological factors of ketamine addicts.Methods:Collect information based on on four diagnostic methods of ketamine addicts, then analyze TCM factors according to syndrome differentiation.Results:Fifty-five cases of ketamine addicts from Fuzhou Ze-xu Voluntary-detoxification Institute (FZVI) and thirty-eight cases of ketamine addicts from Fuzhou Compulsory-detoxification Institute(FCI) were analyzed and they share similar TCM factors．To be specific, the two groups have statistically significant differences in kidney syndrome, Yin deficiency, phlegm and dampness pathological factors of TCM (P<0.05).Conclusion:FZVI and FCI ketamine addicts shared similarities in the distribution of syndrome elements.However, because voluntary drug addicts and compulsory drug addicts are in different psychological phase, TCM pathological factors in kidney, Yin deficiency, phlegm and dampness syndrome are also different with statistical significance(P<0.05).Also, psychological pressure may induce relapse of drug addiction.