To observe the effect of preventive treatment of disease on health status of sub-healthy people.Methods:A hundred cases meeting the sub-health criteria were included and randomly divided into control group and observation group, with 50 cases in each group. Patients in the control group were given conventional intervention, while patients in the observation group had conventional intervention and comprehensive intervention of preventive treatment of disease. Scores of quality of life were compared before and after the intervention after six-month treatment.Results:There were significant differences in the physical, psychological and social relations in the observation group before and after the intervention (P<0.05).Conclusion:Comprehensive health intervention may effectively improve the health status of sub-healthy population and improve the quality of life. TCM preventive treatment of disease may effectively affect sub-health and improve the health conditions.