In recent years, there is marked increase in the incidence and mortality of colorectal cancer, pixu type being amid common syndrome differentiation types. Modern research shows that one of the important factors in colorectal cancer is the intestinal flora. In this article, explanation was made on the relation between intestinal flora and colorectal cancer of pixu type through analyzing the relationship between intestinal flora, their metabolites and colorectal cancer, the mechanism of the occurrence and development of colon cancer caused by imbalance of the intestinal flora, and the relationship between the flora with spleen and stomach from the collected literatures, providing a new theoretical reference for the study of the intestinal flora and prevention and control of colon cancer