To observe the changes of vascular endothelial function indexes of plasma-nitric oxide (NO),superoxide dismutase (SOD),thromboxane B2 (TXB2) and P-selectin of patients with coronary heart disease (CHD) angina by treating with Xuelian Tongmai Pills,and to evaluate the effects of Xuelian Tongmai Pills on vascular endothelial function.Methods:A total of 60 patients with CHD angina in accordance from May 2014 to May 2017 with diagnosis criteria were divided into control group (conventional western medicine treatment group) and treatment group (Xuelian Tongmai Pills+ conventional western medicine treatment),30 cases in each group.The control group was treated with conventional western medicine treatment.The patients were given Aspirin Enteric-coated Tablets 100 mg,qd,Statins (oral administration of Simvastatin Tablets 20 mg,qd),β-receptor blocker (oral administration of bisoprolol 5 mg,qd or metoprolol 25 mg,bid),Nitrates (oral administration of xinkang 40 mg,qd).The treatment course was 8 weeks.The treatment group was added Xuelian Tongmai Pills 9 g per time,bid for 8 weeks.The changes of TCM pattern scores,NO,SOD,TXB2 and P-selectin of patients in two groups after 8 weeks' treatment were observed.Results:1）For TCM pattern,TCM pattern scores of two groups were significantly improved after treatment (P<0.05),and the improvement of treatment group was significantly better than that of control group (P<0.05).For clinical efficacy,the effective rate of treatment group was 60.00%,which was significantly better than 33.33% in control group (P<0.05).The total effective rate of treatment group was 96.7%,which was significantly better than 80% of control group (P<0.05).2）For plasma NO level,plasma NO levels of two groups were increased after treatment,and there was significant difference in treatment group before and after treatment (P<0.05),while the difference was not significant in control group (P>0.05).The difference in plasma NO level of two groups was significant after treatment (P<0.05).3）For plasma SOD level,the plasma SOD levels were increased in both groups after treatment (P<0.05),and the difference in treatment group was significant before and after treatment (P<0.05),while no significant different in control group (P>0.05).The difference in plasma SOD of two groups after treatment was significant (P<0.05).4）For plasma TXB2 and P-selectin levels,the plasma TXB2 and P-selectin levels of two groups were decreased after treatment,and the decrease of treatment group was significant before and after treatment (P<0.05),while no significant difference in control group (P>0.05).When compared between two groups after treatment,the plasma TXB2 and P-selectin levels of treatment group were significantly decreased when compared with that in control group (P<0.05).Conclusion:Xuelian Tongmai Pills can significantly improve the symptoms of patients with CHD stable angina,increase NO and SOD level,strengthen oxidation resistance,decrease TXB2 and P-selectin levels,alleviate vascular endothelium damage,and partially restore the functions of vascular endothelium,which can be inferred that Xuelian Tongmai Pills has protective effect on vascular endothelial function.