Pathogenesis is an important concept in TCM,which is closely related to the theory and practice of TCM.This paper firstly combed the space-time concept in TCM,and then analyze and discuss the spatiotemporal pathogenesis combined with the literature and clinical practice in the philosophical background of TCM theory from the perspective of “intermingling with phlegm and blood stasis”,and proposed that the pathogenesis of TCM is a process of dynamic change with spatial attributes,as well as discussed the research methods of pathogenesis of space-time attribute,in order to help better understand the connotation of pathogenesis and cognitive and thinking of TCM,providing more ideas for the study of pathogenesis.