Phlegm turbidity and blood stasis are main pathogenesis basis for coronary heart disease (CHD),and play a key role in the whole process of CHD.This article firstly discussed CHD with phlegm and blood stasis pattern from its etiology,pathogenesis,treatment and biological basis.Among the biological basis,apoptosis influences the outcome and prognosis of CHD and endoplasmic reticulum autophagy (ER-phagy) is the key point to regulate apoptosis.Therefore this article investigated its role in the CHD with phlegm and blood stasis pattern from apoptosis.