To observe the clinical effects and safety of treating unstable angina of qi deficiency and blood stasis pattern from spleen.Methods:Historical control was conducted as study design.A total of 120 patients with unstable angina of qi deficiency and blood stasis pattern via coronary angiography who were hospitalized in People's Hospital of Fujian University of Traditional Chinese Medicine from August 2012 to August 2014 were enrolled in this study.Coronary artery stenosis occurred in 50%-70% of all the subjects,without any interventional therapy.The subjects were divided into treatment group and control group according to the random digit table,with 60 cases in each group.Patients in treatment group were treated with Sijunzi decoction and Xuefu Zhuyu decoction on the basis of conventional therapy of western medicine,while the patients in control group were treated with conventional therapy of western medicine only.The treatment course was 4 weeks in both groups.The therapeutic effect on angina pectoris,qi deficiency and blood stasis pattern scores,electrocardiogram (ECG),levels of high sensitive C reactive protein (hs-CRP),homocysteine (HCY) before and after treatment were observed in the two groups.The incidence of adverse events within 4 weeks in two groups was compared.Results:There was no statistically significant difference in baseline clinical information between two groups.Total effective rate was 84.21% and 73.33% in treatment group and control group respectively after 4 weeks of treatment (P<0.05).The effects on ECG were observed in the treatment group,showing significant statistical difference in improving ECG to the control group (P<0.05).Qi deficiency and blood stasis pattern scores,levels of hs-CRP and HCY were significantly reduced in treatment group (P<0.01),with significant difference as compared with control group (P<0.01).There was no difference in the incidence of adverse events between the two groups.Conclusion:Treating unstable angina of qi deficiency and blood stasis pattern from spleen was effective and safe.It could improve the effects on angina pectoris,improve clinical symptoms and inhibit the inflammation reaction.