温肾化浊、逐瘀通络为主治疗糖尿病肾病的临床观察
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东莞市医疗卫生科技计划一般项目(2015105101148)——“温肾化浊,逐瘀通络为主治疗糖尿病肾病的临床观察”


Clinical Observation of Treating Diabetic Nephropathy with Warming Kidney and Dissolving Turbidity and Removing Stasis and Dredging Collaterals Method
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    目的:观察温肾化浊、逐瘀通络为主治疗糖尿病肾病的临床疗效。方法:选取2014年2月至2016年2月在广东省东莞市虎门中医院内科门诊确诊和住院后出院转门诊的糖尿病肾病患者60例,采用随机单盲数字分组法随机分为观察组和对照组,每组30例。温肾化浊为对照组、逐瘀通络组为观察组。治疗3个月后,观察2组患者治疗前后生化指标、症状积分,比较2组的治疗效果。结果:治疗后2组FBG、HbA1C和TG等指标均有改善,2组患者治疗前后HbAlc、TG、24 h尿蛋白定、UAER比较差异有统计学意义(P<0.05);2组治疗前后BuN、Cr、CysC、CH、hs-CRP比较差异无统计学意义(P>0.05)。治疗后2组组间比较,观察组24 h尿蛋白定明显减少,差异有统计学意义(P<0.05)。观察组显效率100%,对照组90%,2组比较差异有统计学意义(P<0.05)。2组患者均未出现不良反应。结论:温肾化浊、逐瘀通络为主治疗糖尿病肾病结合西药常规治疗糖尿病肾病疗效优于单纯西药常规治疗。

    Abstract:

    To observe the clinical efficacy of warming kidney and dissolving turbidity and removing stasis and dredging collaterals method in the treatment of diabetic nephropathy.Methods:From February 2014 to 2016,60 patients with diabetic nephropathy in our outpatient hospital were randomly collected and divided into two groups:the treatment group(using Chinese method) and the control group(using western medicine).After 3 months of treatment,two groups were observed before and after treatment for biochemical index and symptom scores,and the therapeutic effect of two groups were compared.Results:After treatment,FBG,HbAlc,TG and other indicators have improved,before and after treatment,HbAlc,TG,24 h urine protein set,UAER of the two groups were significantly different (P<0.05).Before and after treatment,BuN,Cr,CysC,CH,hs-CRP showed no significant difference between the two groups (P>0.05).After treatment,24 h urine protein of the treatment group significantly reduced,and the difference was statistically significant (P<0.05).The efficiency of the treatment group was 100%,and the control group 90%,t=3.157,P<0.05.The difference was statistically significant.Besides,patients in both groups show no adverse reactions.Conclusion:Warming kidney and dissolving turbidity and removing stasis and dredging collaterals methodcombined with conventional western medicine in the treatment of diabetic nephropathy is better than conventional western medicine treatment.

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宋诵文,曾琦,吴新民,宋银枝.温肾化浊、逐瘀通络为主治疗糖尿病肾病的临床观察[J].世界中医药,2017,(09).

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  • 收稿日期:2016-12-06
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  • 在线发布日期: 2017-09-22
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