To investigate the effects of Qilizhenwu decoction on cardiac function and plasma brain natriuretic peptide (BNP) in patients with chronic heart failure. Methods:Using the prospective study method, 112 patients with chronic heart failure who came to our hospital from August 2013 to January 2016 were randomized into an observation group and a control group, 56 cases in each. The control group were treated with routine western medicine, the observation group extra Qilizhenwu decoction, both observed for 4 weeks. Results:After treatment, the total effective rates of the observation group and the control group were 96.4% and 89.3% respectively, observation group significantly higher than that of the control group (P<0.05). The LVEF values in the observation group and control group after treatment were （7.724±5.22）% and （70.24±4.56）%, significantly higher than those before treatment,（60.24±4.20）% and （60.11±5.10）%, (P<0.05), and the LVEF values in the observation group after treatment were significantly higher than those in control group (P<0.05). The plasma BNP values in the observation group and the control group after treatment were （1 673.42±256.30）pg/mL and （1 655.09±309.87）pg/mL, significantly lower than those before treatment, （180.24±45.10）pg/mL and （341.09±50.19）pg/mL, (P<0.05), and observation group was also significantly lower than those in the control group (P<0.05). The low shear and high shear viscosity of whole blood in the observation group after treatment were significantly lower than those before treatment (P<0.05), with significant group differences (P<0.05). Conclusion:Qilizhenwu decoction used in chronic heart function patients can effectively improve the cardiac function and hemodynamics and promote plasma BNP expression decreased to improve the overall treatment effect.