To observe the clinical effect of Compound Danshen dripping pill in the treatment to stable angina pectoris, and its effect on CRP (C reactive protein) and BNP (brain natriuretic peptide). Methods:A total of 100 cases of angina pectoris in our hospital from June -2016, February 2011, were randomly divided into the observation group and the control group, with 50 cases in each group. Observation group: oral compound Danshen dripping pills; control group: oral Isosorbide Mononitrate Sustained Release Tablets. The frequency and duration of angina attack were observed and recorded in two groups, and the CRP and BNP were detected by enzyme-linked immunosorbent assay (ELISA).Results:While angina pectoris attacked, both groups of patients' conditions were better than before the treatment. (P<0.05), and for the observation group, the frequency and duration of pain in angina attacking were less than the control group (P<0.05). The total effective rate of the observation group was better than that of the control group (P<0.05). Inhemorheology, the two groups of Tc and LDL were lower than before the treatment (P<0.05), while HDL were higher at the same time(P<0.05). Comparing TC and LDL of the observation group with TC and LDL of control group, the observation group's were lesser(P<0.05). However, for HDL, observation group was higher than the control group (P<0.05). The two groups after treatment, BNP and CRP were lower than before the treatment (P<0.05), and the observation group decreased more than the control group(P<0.05). Conclusion:Compound Danshen dripping pill is effective in the treatment of stable angina pectoris symptom, and the application in stable angina pectoris can down regulate the expression level of CRP and BNP. The mechanism may be related to the regulation of Compound Danshen dripping pill for biological factors and then play a role in improving the effect of angina pectoris.