To investigate the application of Qi Ming granule combined with tobramycin and dexamethasone,Pranoprofen Eye Drops in DM phaco patients increasing foveal thickness in the prevention of postoperative.Methods:All 98 cases (98 eyes) with diabetes who needed white in ultrasonic emulsification surgery were selected in our hospital from May 2014 to May 2014 according to random number table method.They were all randomly divided into two groups,a control group and a research group,in which the control group received tobramycin dexamethasone eye drops for treatment after surgery,while the research group patients taking extra Pranoprofen Eye Drops,comparing the two groups' ocular findings and concave macular center thickness before and after treatment.Results:Two groups of patients' postoperative BCVA significantly were higher than before (P<0.01); and 1 months after surgery and 3 months after operation in the research group,BCVA was significantly higher than that of the control group (P<0.05).The foveal thickness in the two groups after operation were significantly higher than that of preoperative (P<0.01); and 3 months after operation test of the foveal thickness were (166.88±15.90) m,significantly lower than that of the control group (173.15±16.60) m (P<0.05).There were 3 cases (6.12%) patients with macular edema in the research group,while 3 patients (18.37%) in the control group had macular edema after 9 months of operation.Conclusion:In phacoemulsification after the combined application of tobramycin and dexamethasone in patients with diabetes mellitus and Qiming granules and Pranoprofen Eye Drops,the incidence of postoperative macular edema was significantly reduced,and the postoperative increase of foveal thickness was effectively prevented.