To observe the clinical efficacy of San Huang decoction(SHD) on improving inflammation of surgical wound after operation in patients with breast cancer and discuss its role in accelerating recovery and prognosis. Methods:A total of 30 breast cancer patients who met the inclusion/exclusion criteria were randomized in to treatment group(n＝15) and control group(n＝15). Patients in the control group were given routine treatment. On that basis, patients in the treatment group were given liquid SHD, one dose, twice a day. Treatment was given from 1 day before to surgery and 7 days after. Records measured include traditional Chinese medical symptoms, local wound inflammatory symptoms, quantity and sum of drainage fluid and the levels of C reactive protein (CRP)，Interleukin-6(IL-6) Interleukin-2 (IL-2), Interleukin-8(IL-8), tumor necrosis factor-alpha (TNF-α) from drainage fluid on the surgery day, and after 1, 3, and 7 days of surgery. Results:Compared to control group, traditional Chinese medical symptom scores decreased significantly in the treatment group (P<0.05) as well as the scores of surgical wound inflammatory symptoms. Drainage fluid was reduced significantly with 572.2 mL in the treatment group compared to 700.4 mL in the control group(P<0.05). Levels of CRP，IL-6, IL-2R,IL-8 and TNF-alpha were significantly lower in the treatment group at day 3 and 7 after surgery compared to those in the control group(P<0.05). Conclusion:SHD can effectively reduce the local wound inflammation and improve recovery after breast cancer operation.