To observe the clinical curative of Turtle Carapace Decoction Pill on chronic hepatitis B patients with earlier period cirrhosis,and on TNF-α and MMP-2.Methods:A total of 80 chronic hepatitis B patients with earlier period cirrhosis from November 2013 to December 2015 in our hospital were studied,and they were randomly divided into the control group (40 cases) and the study group (40 cases).Both of the two groups received polyene phosphatidylcholine capsule to improve liver function,and entecavir antiviral treatment.The study group was treated with Turtle Carapace Decoction Pill based on the treatment of the control group,and then two groups of patients after 12 weeks' treatment regarding liver function,liver fibrosis indexes,color doppler ultrasound of liver,and the concentration changes of peripheral blood T TNF-α and MMP-2 were compared.Results:1) The liver function,liver fibrosis indexes and color doppler ultrasound results of both two groups were better after the treatment,and the study group received better results compared with the control group,the differences were statistically significant (P<0.05); 2) The TNF-α and MMP-2 levels in peripheral blood decreased in the two groups after treatment,the downtrend of study group was obvious than that of the control group,the differences were statistically significant (P<0.05).Conclusion:Turtle Carapace Decoction Pill can obviously improve the health condition of early cirrhosis of chronic hepatitis B patients,and the mechanism may be related to decreased TNF-α and MMP-2 levels in peripheral blood.