To analyze the clinical curative effect of Ziyintiaojing Granules in the treatment of climacteric dysfunctional uterine bleeding of liver and kidney yin deficiency type.Methods:The objects of this study are 80 cases of climacteric dysfunctional uterine bleeding of liver and kidney yin deficiency type who were in our hospital from February 2014 to February 2016,dividing into a study group and a control group,each of 40 cases.Patients of the control group were given Gongxuening capsules and those of the other group were given Ziyintiaojing Granules.The clinical efficacy,serum sex hormone index and coagulation function before and after treatment were observed.Results:The total effective rate of the study group was 92.50%,higher than that of the control group,72.5%(P<0.05); the difference of serum sex hormone index between the two groups before treatment was small (P>0.05); after treatment,FSH (11.29±3.62) mIu/mL,LH（12.30±3.46）mIu/mL,E2（85.73±5.82）pg/mL and other indicators of the study group were better than those of the control group (P<0.05); as to coagulation,the two groups did not show much difference be treatment(P>0,05); after treatment,PT(10.20±1.38)s and APTT(23.10±3.51)s of the study group had more advantages compared with the control group(P<0.05).Conclusion:Ziyintiaojing Granules have significant effect in the treatment of climacteric dysfunctional uterine bleeding of liver and kidney yin deficiency type,which improves serum sex hormone and blood coagulation indexes and could be applied clinically.