To observe clinical efficacy of pure moxibustion combined with pinaverium bromide in spleen and kidney deficiency type of irritable bowel syndrome with diarrhea(IBS-D).Methods:Eighty patients were randomly divided into a control group and a treatment group ( 40 patients for each) by random number table method,and the control group received pinaverium bromide treatment while the treatment group extra pure moxibustion.The treatment course was 6 weeks for both groups.The clinical effect before and after treatment was observed together with the main symptoms (abdominal pain,diarrhea,bloating,defecation and pulpy stools).IBS Quality of Life Questionnaire was used for the evaluation of two groups (emotion,sleep,diet,daily activities and work).Results:The total effective rate of the control group was 77.50% and the treatment group 95.00%,the treatment group better than that of the control group; Symptom scores of the treatment group were significantly lower than that of the control group,however,scores of quality of life \ were significantly higher.Conclusion:Pure moxibustion combined with pinaverium bromide has significant effect in irritable bowel syndrome with diarrhea,and improves the quality of life of patients.