To evaluate the clinical effect of Liquorice Root Decoction in the treatment of atrial fibrillation (AF).Methods:The references of randomized controlled trials of Liquorice Root Decoction in the treatment of AF were searched from CNKI,VIP,and Wanfang Database published from January 2000 to April 2017.The articles were screened again and graded by Jadad Quality Scale.RevMan 5.3 was used for the meta-analysis.Results:Liquorice Root Decoction had a significant effect in improving the clinical symptoms of AF (OR=1.89,95% CI 1.24～2.86,P=0.003,I2=45%).It had advantages over conventional Western medicine therapy alone in conversing to sinus rhythm on ECG (or 24 hour dynamic electrocardiogram) (OR=2.70,95% CI 1.71～4.26 P<0.0001，I2=7%).Conclusion:Liquorice Root Decoction may have a certain effect in the treatment of AVMC.