Moxibustion,as a simple,safe and effective treatment,has been handed down to generations.The researches on the mechanism of moxibustion are numerous.Moxa-smoke as one of the essential elements of moxibustion's effectiveness is getting attention from more and more scholars in recent years.Based on current research situation,the authors study the moxa-smoke from two aspects,which are the functional mechanism and its safety,and explore the development direction of moxa-smoke and further expand the scope of its application.